Allergy medications that are not non sedating antihistamines

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This agent interferes with mediators release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells.

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Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist.

In addition fexofenadine may also inhibit the late-phase allergic reaction by acting on leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect.

Overall, this agent blocks the actions of endogenous histamine, thereby leads to temporary relief of the negative symptoms associated with histamine and achieve effects such as decreased vascular permeability, reduction of pruritus and localized smooth muscle relaxation.alpha-(4-(1-carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol, fexofenadine, fexofenadines (medication), fexofenadines, FEXOFENADINE, fexofenadine [Chemical/Ingredient], Fexofenadine, Fexofenadine (product), Fexofenadine (substance)telfast, allegra, allegra [brand name], Telfast, Aventis Behring brand of fexofenadine hydrochloride, Aventis Pharma brand of fexofenadine hydrochloride, Aventis brand of fexofenadine hydrochloride, Hoechst brand of fexofenadine hydrochloride, Allegra A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists.

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